Potato tuber moth (PTM), Phthorimaea operculella(Lepidoptera: Gelechiidae) is one of the serious worldwide pest of potato (Solanum tuberosumL. Solanaceae). This pest by making irregular tunnels leaves excreta behind and led to a considerable yield loss. Trials were conducted to evaluate the effect of Bacillus thuringiensisisolate against newly emerged larvae of PTM. It had been found that the total larval death recorded 14 and 58% of larval death at 1.25 and 10 CFU/ml, respectively. The potential of extract of Artemisia judaicaagainst PTM larvae showed increase in larval mortality from 34 to 76% at 125 to 1000 ppm, respectively. In this study, the effect of Artemisia judaicaextracton Phthorimaeaoperculella larval instar was more effective thanthe effect ofBacillusthuringiensisisolate. In order to get the best results when using two bio-control agents in IPM strategies, bacteria should be used first and then the plant extract.